Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.

TitleCase Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.
Publication TypeJournal Article
Year of Publication2018
AuthorsDenning, DW, Page, ID, Chakaya, J, Jabeen, K, Jude, CM, Cornet, M, Alastruey-Izquierdo, A, Bongomin, F, Bowyer, P, Chakrabarti, A, Gago, S, Guto, J, Hochhegger, B, Hoenigl, M, Irfan, M, Irurhe, N, Izumikawa, K, Kirenga, B, Manduku, V, Moazam, S, Oladele, RO, Richardson, MD, Tudela, JLuis Rodri, Rozaliyani, A, Salzer, HJF, Sawyer, R, Simukulwa, NF, Skrahina, A, Sriruttan, C, Setianingrum, F, Wilopo, BAP, Cole, DC, Getahun, H
JournalEmerg Infect Dis
Date Published2018 Aug

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.

Alternate JournalEmerging Infect. Dis.
PubMed ID30016256
PubMed Central IDPMC6056117